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An epidemic at a dive meet leads to a discovery about a young girl's health.
A young college student collapses after an intense romantic encounter with his girlfriend.
Hugh Laurie (Dr. Gregory House), Robert Sean Leonard (Dr. James Wilson), Lisa Edelstein (Dr. Lisa Cuddy), Omar Epps (Dr. Eric Foreman), Jennifer Morrison (Dr. Allison Cameron), Jesse Spencer (Dr. Robert Chase). 📂 Updated Episode Directory (Index)
Here is the complete episode list for the first season, which originally aired from November 16, 2004, to May 24, 2005..
A woman has African sleeping sickness, implying potential adultery. 25 Jan 2005
Index of House M.D. Season 1 Updated: The Complete Episode Guide (2026)
A major league baseball player on the verge of a comeback suffers a bone fracture and breathing issues.
A 10-year-old overweight girl suffers a sudden heart attack on the school playground.
Billionaire Edward Vogler (Chi McBride) buys his way into becoming the Chairman of the Board, introducing the season's primary antagonist. Episode 15: "Mob Rules" Original Air Date: March 22, 2005
Season 1 establishes the series’ signature procedural formula: a mysterious patient presents with baffling symptoms, House’s team runs tests and frequently reaches incorrect diagnoses, complications arise, House proposes a daring hypothesis, and the final diagnosis typically involves an ethical dilemma or personal cost. The season’s 22 episodes refine this template while varying pacing and emotional stakes.
Head of Oncology and House’s fiercely loyal, albeit long-suffering, best friend. Updated Complete Episode Index: House M.D. Season 1
Neurocysticercosis (a tapeworm infestation in the brain) contracted from eating undercooked pork.
A young kindergarten teacher loses her ability to speak and suffers from seizures.
Availability varies by country, but the series is regularly rotated onto the platform globally.
A teen has night terrors; House finds a secret regarding his paternity. 30 Nov 2004
Delves into House's aggressive atheism and his complex views on faith and sacrifice. Episode 6: "The Socratic Method" Original Air Date: December 21, 2004
– A 10-year-old girl with obesity suffers a heart attack, causing House to confront prejudices.
This season quickly established the show's signature formula: a mysterious case, a series of wrong diagnoses, and House's unorthodox methods, all culminating in a dramatic reveal. The season finale, "Honeymoon," sets the stage for a compelling Season 2 arc, making it an ideal starting point for any viewer.
An epidemic at a dive meet leads to a discovery about a young girl's health.
A young college student collapses after an intense romantic encounter with his girlfriend.
Hugh Laurie (Dr. Gregory House), Robert Sean Leonard (Dr. James Wilson), Lisa Edelstein (Dr. Lisa Cuddy), Omar Epps (Dr. Eric Foreman), Jennifer Morrison (Dr. Allison Cameron), Jesse Spencer (Dr. Robert Chase). 📂 Updated Episode Directory (Index)
Here is the complete episode list for the first season, which originally aired from November 16, 2004, to May 24, 2005..
A woman has African sleeping sickness, implying potential adultery. 25 Jan 2005
Index of House M.D. Season 1 Updated: The Complete Episode Guide (2026)
A major league baseball player on the verge of a comeback suffers a bone fracture and breathing issues.
A 10-year-old overweight girl suffers a sudden heart attack on the school playground.
Billionaire Edward Vogler (Chi McBride) buys his way into becoming the Chairman of the Board, introducing the season's primary antagonist. Episode 15: "Mob Rules" Original Air Date: March 22, 2005
Season 1 establishes the series’ signature procedural formula: a mysterious patient presents with baffling symptoms, House’s team runs tests and frequently reaches incorrect diagnoses, complications arise, House proposes a daring hypothesis, and the final diagnosis typically involves an ethical dilemma or personal cost. The season’s 22 episodes refine this template while varying pacing and emotional stakes.
Head of Oncology and House’s fiercely loyal, albeit long-suffering, best friend. Updated Complete Episode Index: House M.D. Season 1
Neurocysticercosis (a tapeworm infestation in the brain) contracted from eating undercooked pork.
A young kindergarten teacher loses her ability to speak and suffers from seizures.
Availability varies by country, but the series is regularly rotated onto the platform globally.
A teen has night terrors; House finds a secret regarding his paternity. 30 Nov 2004
Delves into House's aggressive atheism and his complex views on faith and sacrifice. Episode 6: "The Socratic Method" Original Air Date: December 21, 2004
– A 10-year-old girl with obesity suffers a heart attack, causing House to confront prejudices.
This season quickly established the show's signature formula: a mysterious case, a series of wrong diagnoses, and House's unorthodox methods, all culminating in a dramatic reveal. The season finale, "Honeymoon," sets the stage for a compelling Season 2 arc, making it an ideal starting point for any viewer.